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Today's Featured Story 2 Small-Cap Biotechs That Could Reward Patient InvestorsWritten by Chris Markoch. Published 12/12/2025. 
Key Points - Small-cap biotech stocks like Mainz Biomed and NanoViricides offer high risk but the potential for outsized returns as their diagnostic and antiviral pipelines advance.
- Mainz Biomed’s ColoAlert test provides early commercial traction, but limited revenue and ongoing cash needs continue to pressure MYNZ stock.
- NanoViricides’ nanomedicine antiviral platform shows promising preclinical data, yet NNVC remains a speculative bet dependent on new funding and pipeline progress.
Speculative investors and patience rarely go hand in hand. Nevertheless, if you're looking to invest in the small-cap biotech sector, patience is a requirement. Most, if not all, of these companies are still in the clinical stage, meaning they have no commercially available drugs or therapeutics. It also means these companies have negative earnings (i.e., are not profitable) and little to no revenue. Success often hinges on the outcome of a single clinical-stage drug or therapeutic. While market uncertainty could send some of America's most popular stocks crashing down even further in 2026 …
This secret has identified three under-the-radar picks that could thrive in 2026 and beyond.
To learn their names and ticker symbols for FREE … Click here NOW — before it's too late. Even if a product advances through trials, profitability may still be years away; only then do companies typically receive the analyst coverage that attracts institutional investment. However, getting in on one of these medical stocks and having it hit is like winning the lottery. In an instant, investors could see 3x, 5x, or even 10x returns. Others may never pan out. That's why many investors interested in penny stocks will distribute a lump sum equally across several biotech companies. If it's a numbers game, diversification can be an effective strategy. With that in mind, let's examine two small-cap biotech stocks that carry significant risks but also the potential for outsized returns. Mainz Biomed: Early Cancer Detection With High Upside Potential Mainz Biomed AG (NASDAQ: MYNZ) is a German molecular diagnostics company that specializes in epigenetics-based tests for the early detection of cancer. Unlike many penny stocks, Mainz Biomed already has a commercial product: ColoAlert – the first DNA-based screening tool for colorectal cancer in Europe. On Dec. 2, Mainz Biomed announced that ColoAlert was added to the portfolio of DoctorBox, one of Germany's leading pioneers in digital health. With over 60,000 new colorectal cancer cases annually in Germany, the market opportunity is meaningful. Mainz Biomed is also developing a non-invasive blood-based screening test for the early detection of pancreatic cancer. The company reported positive topline results in October, but commercial approval is still years away. The risks are substantial. ColoAlert is not yet available in the United States, and even with early sales in Europe and plans to expand into South America, revenue remains minimal. That's why the company included “Going Concern” language in its Sept. 26 SEC filing. Since then, Mainz Biomed filed a $150 million mixed shelf offering. For now, that appears sufficient to keep MYNZ above $1 and avoid a delisting notice. The company is in a race to generate enough revenue to move the needle. If successful, even a small investment could yield a sizable return. NanoViricides: High-Risk Antiviral Play With Breakthrough Potential NanoViricides Inc. (NYSE: NNVC) is another micro-cap biotech that offers a potentially disruptive approach to antiviral treatment and carries significant financial risk that speculative investors should weigh carefully. The company is developing a novel class of antiviral therapies based on its proprietary “nanoviricide” platform. These drug candidates are designed to mimic human cell surfaces and lure viruses into binding with them, effectively neutralizing the pathogens before they can infect real cells. It's an innovative concept that, if validated in human trials, could represent a new method for treating infectious diseases. NanoViricides' current pipeline includes candidates targeting shingles (varicella-zoster virus), HSV-1 and HSV-2, and broad-spectrum influenza. Its shingles program, NV-HSC, is the most advanced, with encouraging preclinical data suggesting strong antiviral activity. As with many micro-cap biotechs, NanoViricides remains pre-revenue and reliant on fresh capital to keep programs moving. The company reported limited cash on hand in recent filings, and investors should expect the possibility of future dilution. Still, if one of its candidates advances successfully into clinical development, the valuation upside could be substantial. For investors with patience and a high tolerance for risk, NNVC represents a genuine moonshot in the antiviral space.
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