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Just For You 3 Big Short Interest Names With Bullish SetupsWritten by Ryan Hasson. Published 9/22/2025. 
Key Points - Market momentum remains strong, with speculation rising but not at extreme levels, creating room for further upside.
- HIMS, DLO, and TEM each combine bullish technical setups with elevated short interest, making them prime candidates for potential squeezes.
- While speculation may eventually cool, the current backdrop supports momentum, and these names stand out as high-upside potential opportunities.
Last week, several high–short interest, momentum-driven stocks broke out as the broader market hit fresh highs. While euphoria inevitably raises questions about sustainability, history shows momentum can carry much further than skeptics expect. As Warren Buffett famously quipped, "The market can remain irrational longer than investors can stay solvent." Currently, the Fear & Greed Index sits at 62—indicating greed but not yet extreme—and the SPDR S&P 500 ETF Trust (NYSEARCA: SPY) holds an RSI of 71, stretched but not at an extreme. In other words, there may still be room for momentum to run. Against this backdrop, three heavily shorted stocks stand out with technical setups that could fuel further upside if sentiment remains supportive. HIMS: On the Cusp of a Breakout Something unusual is happening inside a 40-person crypto research firm.
They're helping 8,000+ ordinary people pull consistent profits from crypto — not through luck or timing, but through a systematic approach with a documented 93% win rate. Claim Your Free Trade Setup → This year, Hims & Hers Health (NYSE: HIMS) has drawn intense scrutiny—from Washington regulators probing its advertising practices to a recent FDA release of over 100 letters to companies, including Hims & Hers, as part of a broader crackdown on drugmakers' marketing. Despite these headwinds, HIMS has surged 139% year-to-date and 259% over the past twelve months. Technically, it has been consolidating since May in a range of roughly $40 to $65. Last Friday, shares pushed toward the $60 level, signaling a potential retest of resistance near $65. What makes this setup especially compelling is a 38% short interest, equating to more than 74 million shares sold short. A decisive break above $65 could trigger a powerful short squeeze, adding fuel to an already strong trend. DLO: Earnings Catalyst Meets Heavy Shorts DLocal Limited (NASDAQ: DLO), a fintech specialist in cross-border payments across emerging markets, has quietly outperformed this year. After its latest earnings release—where it beat both revenue and earnings estimates—shares have climbed nearly 40% year-to-date. Wall Street has taken notice, lifting DLO's consensus price target from $12.45 three months ago to $14 and issuing multiple upgrades. On the technical side, DLO sits just above $15 and faces gap resistance near $16. With 23.4% of its float sold short (nearly 15 million shares), holding above current levels and clearing $16 could unleash fresh momentum and open the door to price discovery. TEM: A High-Short AI Healthcare Play Tempus AI (NASDAQ: TEM) has been one of 2025's standout performers, rallying over 160% year-to-date. The company leverages artificial intelligence and machine learning for precision medicine, with a core focus on oncology—providing genomic profiling, digital pathology, and data-driven insights for personalized cancer care. Shares are now consolidating just below their all-time high near $91, setting up a clear technical level to watch. With 25% short interest, TEM is poised for a breakout if it can decisively clear resistance. Given the early innings of the AI-healthcare narrative and the heavy bearish bet, a squeeze could propel the stock significantly higher. Momentum Remains Intact While the broader market may be stretched, momentum remains firmly intact—and high–short interest names often benefit most in such environments. HIMS, DLO, and TEM each combine strong technical setups with elevated short interest, setting the stage for potential squeezes if bullish momentum continues. Speculation will cool at some point, but for now the backdrop remains supportive. For investors watching the tape, these three names offer some of the most intriguing bullish setups in today's market.
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