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3 Big Short Interest Names With Bullish Setups
Written by Ryan Hasson. Published 9/22/2025.
Key Points
- Market momentum remains strong, with speculation rising but not at extreme levels, creating room for further upside.
- HIMS, DLO, and TEM each combine bullish technical setups with elevated short interest, making them prime candidates for potential squeezes.
- While speculation may eventually cool, the current backdrop supports momentum, and these names stand out as high-upside potential opportunities.
Last week, several high short-interest, momentum-driven stocks broke out strongly, riding speculation as the broader market hit fresh highs. Although this euphoria raises questions about sustainability, history shows momentum can persist longer than skeptics anticipate.
As Warren Buffett famously said, "The market can remain irrational longer than investors can stay solvent."
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The Fear & Greed Index sits at 62—reflecting greed but not yet extreme—and the SPDR S&P 500 ETF Trust (NYSEARCA: SPY) holds an RSI of 71, stretched but not extreme. In other words, momentum may still have room to run. Against this backdrop, three heavily shorted stocks stand out with technical setups that could fuel further upside if sentiment remains supportive.
HIMS: A Retail Favorite on the Edge of a Breakout
This year, Hims & Hers Health (NYSE: HIMS) has drawn scrutiny from Washington regulators over advertising practices and the telehealth distribution of GLP-1 weight-loss drugs. Last week, the FDA posted more than 100 letters to companies, including Hims & Hers, as part of a broader crackdown on pharmaceutical corporations.
Despite these headwinds, the stock's performance has been extraordinary: shares are up 139% year-to-date and 259% over the past twelve months. Technically, HIMS has been consolidating since May between $40 support and $65 resistance. Last Friday, the stock pushed toward $60, suggesting a potential retest of that upper range.
What makes this setup compelling is the 38% short interest—over 74 million shares sold short. A decisive break above $65 could spark a powerful squeeze, adding fuel to its already strong momentum.
DLO: Strong Earnings Meet Heavy Shorts
DLocal Limited (NASDAQ: DLO), a fintech specializing in cross-border payments, enjoyed a breakout after its latest earnings release, beating both revenue and earnings estimates. Shares are now up nearly 40% year-to-date.
Wall Street has taken notice, lifting the consensus price target from $12.45 three months ago to $14, alongside multiple upgrades. Yet DLO still carries a hefty 23.4% short interest, equal to roughly 15 million shares.
Trading just above $15, the stock needs to hold this level and clear earnings-gap resistance near $16 to trigger further momentum and open the door to price discovery.
TEM: A High-Short AI Healthcare Play
Tempus AI (NASDAQ: TEM) has been one of 2025's top performers, with shares up more than 160% year-to-date on its artificial intelligence and machine-learning solutions in precision medicine. The company focuses on oncology, offering genomic profiling, digital pathology, and data-driven insights for personalized cancer care.
Technically, TEM has been consolidating below its all-time high near $91, forming a clear pivot point. With 25% short interest, the stock is primed for a breakout if it decisively clears resistance. As the AI healthcare narrative remains in its early innings, the risk of a short squeeze adds to its upside potential.
Momentum Remains Firmly Intact
While the broader market may be stretched, momentum remains intact, and high short-interest names often lead in such environments. HIMS, DLO, and TEM combine strong technical setups with elevated short interest, creating fertile ground for further upside if bullish sentiment persists. Though speculation inevitably cools at some point, these three names stand out as some of the most intriguing bullish setups in today's market.
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