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Further Reading from MarketBeat Media Small-Cap Standouts: These 3 Stocks Rose Over 300% in 2025Reported by Leo Miller. First Published: 1/3/2026. 
Article Highlights - While small caps as a whole generated lower returns than large caps in 2025, three interesting names bucked this narrative.
- A cancer screening company and two satellite operators saw their shares rise 300% or more.
- See where analysts are forecasting upside and understand vital considerations pertaining to smaller stocks.
In 2025, small-cap stocks underperformed their large-cap peers. The Russell 2000 Index, which tracks 2,000 U.S. small-cap stocks, delivered a total return of roughly 13% in 2025 — well below the S&P 500 Index's total return of about 18%, which tracks large-cap U.S. stocks. Despite the broader lag, three names stood out for exceptional performance in 2025. Below, we highlight three stocks that returned 300% or more during the year. Each began 2025 in small-cap territory but, because of those gains, has since moved into mid-cap territory. GRAIL Catapults on Early Cancer Detection Enthusiasm A free report revealing the 7 key indicators that have predicted every major economic collapse since 1929.
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These aren't the signals you'll see on CNBC. Claim Your Free Report Now » Healthcare stock GRAIL (NASDAQ: GRAL) climbed roughly 380% in 2025. The company's market capitalization rose from well under $1 billion to about $3.3 billion. GRAIL's main product is the Galleri multi-cancer early detection test. Early detection greatly improves cancer survival rates, which has driven strong interest in Galleri. Only about five cancer types have standardized screening methods, yet roughly 70% of cancer deaths come from cancers outside those five. Galleri is designed to detect more than 50 cancer types. In a recent study, GRAIL reported that adding Galleri to traditional screening increased early cancer detection by more than sevenfold. Today, most Galleri revenue comes from out-of-pocket payments. GRAIL expects to apply for Premarket Approval (PMA) from the U.S. Food and Drug Administration in the first quarter of 2026; if approved, commercial insurers would be far more likely to cover the test, unlocking a much larger sales channel. That potential approval is a key driver of investor enthusiasm. The MarketBeat consensus price target of $97.50 reflects analyst optimism and implies roughly 14% upside from current levels. PL Blasts Off, Combining AI with Geospatial Imagery Planet Labs PBC (NYSE: PL) enjoyed a blockbuster 2025, with shares rising just under 390%. Planet operates hundreds of satellites that capture medium- to high-resolution Earth imagery and combines that data with artificial intelligence to help customers make better decisions. Revenue comes primarily from subscriptions to its cloud platform and satellite services. Demand has been strongest among government customers. Its Dec. 10 earnings report sent shares up 35% in a single day, driven by defense and intelligence revenue that rose more than 70%. The company reported a backlog of about $735 million — roughly 2.6 times its last 12 months' revenue of $282 million — which could support meaningful growth. Planet Labs also recorded positive free cash flow for the second consecutive quarter. The MarketBeat consensus price target of $14.74 implies about 25% downside. However, analyst targets updated after the recent earnings report average $18.19, which would imply roughly 7.7% downside. Planet Labs remains worth watching; a significant pullback could create an attractive entry point for long-term investors. Updated Targets Eye Strong Upside in VSAT After Huge 2025 Run Finally, Viasat (NASDAQ: VSAT) gained about 305% in 2025, giving it a market cap near $4.7 billion. Viasat is another satellite services company, focused on internet and data connectivity for aviation, maritime and government customers — somewhat similar in concept to AST SpaceMobile (NASDAQ: ASTS), but with different end markets. Viasat provides in-flight wireless connectivity to thousands of commercial and business aircraft. The U.S. government was the company's largest customer in fiscal 2025, accounting for 18% of revenue. (Viasat is currently in fiscal 2026.) Revenue grew by just 2% last quarter, but awards rose 17% to nearly $1.5 billion and the backlog climbed to almost $3.9 billion. The MarketBeat consensus price target of $32.75 suggests about 5% downside. Targets updated after Viasat's Nov. 7 earnings report, however, average $49, implying roughly 37% upside — a markedly different view from earlier estimates. GRAL, PL, VSAT: Deep Research Is Paramount GRAL, PL and VSAT produced breathtaking returns in 2025, but investors should remember that smaller-cap stocks — especially those that have just run up dramatically — can be highly volatile. Confidence in the long-term outlook and disciplined research are essential before committing capital. As always, perform thorough due diligence and consider how these stocks fit with your risk tolerance and portfolio goals.
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