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Today's Exclusive Content Small-Cap Standouts: These 3 Stocks Rose Over 300% in 2025Author: Leo Miller. First Published: 1/1/2026. In 2025, small-cap stocks underperformed. The Russell 2000 Index, which tracks the performance of 2,000 U.S. small-cap stocks, returned roughly 13% in 2025. That was notably below the S&P 500 Index's total return of about 18%, which tracks U.S. large-cap stocks. Despite the broader small-cap lag, three names stood out for their exceptional performance in 2025. Below, we detail three stocks that delivered returns of 300% or more. This analysis focuses on companies that began 2025 in small-cap territory but, after their gains, have since moved into mid-cap range. All data are as of the Dec. 31 close unless otherwise indicated. GRAIL Catapults on Early Cancer Detection Enthusiasm Healthcare stock GRAIL (NASDAQ: GRAL) rose by approximately 380% in 2025. The company's market capitalization moved from well below $1 billion to around $3.3 billion. GRAIL's main product is its Galleri multi-cancer early detection test. If you want a way to generate consistent market income without chasing volatile AI stocks or complex crypto trades, you'll want to see my new e-book, How To Master The Retirement Trade. It reveals a simple, time-based strategy that targets trades designed to play out in as little as 11 hours — no guesswork, no hype. Claim your free copy of How To Master The Retirement Trade now Quick Look - While small caps as a whole generated lower returns than large caps in 2025, three interesting names bucked this narrative.
- A cancer screening company and two satellite operators saw their shares rise 300% or more.
- See where analysts are forecasting upside and understand vital considerations pertaining to smaller stocks.
Early detection greatly improves cancer survival rates, which has driven strong interest in the product. Notably, only about five cancer types have standardized screening methods, yet roughly 70% of cancer deaths come from other types. GRAIL designed Galleri to detect more than 50 different cancers. In a recent study, GRAIL reported that Galleri increased early cancer detection by more than seven times when added to traditional screening. Currently, Galleri's sales are largely out-of-pocket. GRAIL expects to apply for Premarket Approval (PMA) from the U.S. Food and Drug Administration in Q1 2026. If granted, that approval would substantially increase the likelihood that commercial insurers cover the test, potentially unlocking a major new sales channel. Overall, the prospect of approval has fueled investor enthusiasm. The MarketBeat consensus price target of $97.50 reflects analyst optimism, implying roughly 14% upside. PL Blasts Off, Combining AI with Geospatial Imagery Planet Labs PBC (NYSE: PL) had an enormous 2025, with shares rising nearly 390%. Planet operates a large constellation of satellites that capture medium- to high-resolution images of Earth. By combining that imagery with artificial intelligence, Planet seeks to help customers make better decisions. The company generates revenue from subscriptions to its cloud-based platform and satellite services. Demand appears to be materializing, especially among government customers. Its Dec. 10 earnings report sent shares up 35% in a single day, with defense and intelligence revenue rising more than 70%. The firm reported a backlog of about $735 million — roughly 2.6 times its trailing 12-month revenue of $282 million — offering a pathway for significant growth. Planet Labs also posted positive free cash flow for the second consecutive quarter. The MarketBeat consensus price target of $14.74 implies about 25% downside. However, the average of targets updated after the company's latest earnings report is $18.19, which would imply roughly 7.7% downside. Overall, Planet Labs is worth watching; any meaningful pullback could present a more attractive entry. Updated Targets Eye Strong Upside in VSAT After Huge 2025 Run Last is Viasat (NASDAQ: VSAT), which gained about 305% in 2025, bringing its market cap to roughly $4.7 billion. Viasat is another satellite company but focuses on internet and data connectivity rather than primarily on consumer mobile networks. It targets aviation, maritime and government customers, making it comparable in some ways to AST SpaceMobile (NASDAQ: ASTS). For example, Viasat provides in-flight wireless connectivity to thousands of commercial and business aircraft. The U.S. government was the firm's largest customer in fiscal 2025, accounting for 18% of revenue. (Viasat is currently in fiscal 2026.) Revenues grew only 2% in the most recent quarter, but awards rose 17% to nearly $1.5 billion and backlog climbed to almost $3.9 billion. The MarketBeat consensus price target of $32.75 implies about 5% downside. However, price targets updated after Viasat's Nov. 7 earnings report average $49, suggesting roughly 37% upside potential. GRAIL, Planet Labs, Viasat: Deep Research Is Paramount Overall, GRAIL, Planet Labs and Viasat delivered spectacular returns in 2025. While these stocks are compelling, investors should recognize that smaller companies — especially those that have posted large, rapid gains — can be highly volatile. Having conviction in their long-term outlook is important, and investors should conduct thorough due diligence before making investment decisions.
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