| Sources: SHPH Website. SHPH Presentation. -----
And as I mentioned above, (Nasdaq: SHPH) has several potential catalysts to consider this moment. Take a look:
No. 1 SHPH Potential Catalyst - Could This Tiny Float Create A Scenario For Strong Volatility Potential?
According to the Yahoo Finance website, SHPH has a really tiny low float.
In fact, the website reports this profile to have approximately 987.08k shares in its float.
Why is that important? It's important on one crucial level. Volatility potential.
If the company provides positive company news towards the end of 2025, could it provide a near term spark when paired with this volatility potential? -----
No. 2 SHPH Potential Catalyst - A Binding Term Sheet Moves SHPH That Much Closer To A Game-Changing Acquisition.
Shuttle Pharmaceuticals to Acquire AI Molecular Modeling and Predictive Analytics Platform
Rockville, Maryland--(Newsfile Corp. - October 21, 2025) - Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH) ("Shuttle" or the "Company") today announced that it has entered into a binding term sheet with 1542770 BC Ltd. ("Molecule"), a Canadian artificial intelligence company specializing in molecular discovery and drug development technologies.
Under the terms of the agreement, Shuttle or one of its affiliates will acquire substantially all of Molecule's assets and liabilities for a total purchase price of $10Mn, payable in a combination of cash and shares of Shuttle common st-ock. The exact mix of cash and equity will be determined by Shuttle at its sole discretion and will be paid over time, subject to the achievement of certain performance milestones.
The parties intend to finalize one or more definitive agreements to complete the transaction, which will include customary representations, warranties, and closing conditions. The closing of the acquisition will be subject to, among other things, satisfactory completion of mutual due diligence and the execution of the final transaction documents.
"This proposed acquisition represents an important strategic step toward expanding Shuttle's technological capabilities and advancing our mission of developing precision radiotherapy solutions," said Chris Cooper, Chief Executive Officer of Shuttle Pharmaceuticals. "Molecule's AI platform offers cutting-edge tools for molecular modeling and predictive analytics that can enhance our drug discovery and development pipeline."
Read the full article here. -----
No. 3 SHPH Potential Catalyst - A Recent Corporate Update Points To Transformative Company Milestones.
Shuttle Pharma Provides Second Quarter 2025 Corporate Update
GAITHERSBURG, Md., Aug. 14, 2025 (GLOBE NEWSWIRE) -- Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) (“Shuttle Pharma” or the “Company”), a discovery and development stage specialty pharmaceutical company focused on improving outcomes for cancer patients treated with radiation therapy (RT), today provided a corporate update.
Recent Activities:
- Patient enrollment in the Company’s Phase 2 clinical trial of Ropidoxuridine for treatment of patients with glioblastoma reached 63% in the initial randomized portion of the trial.
- 72% of the enrolled patients have completed all seven cycles.
- Ropidoxuridine is being reported by treatment sites as well tolerated.
- Ended the quarter with $4.8Mn in cash following the closing of a private placement pursuant to a securities purchase agreement with an accredited in-vest-or for aggregate gross proceeds of $4.25Mn in June 2025.
- Completed a reverse st-ock split in June 2025 as part of strategic Nasdaq compliance initiative.
- Appointed George Scorsis as the Chairman of the Board of Directors and appointed Christopher Cooper, our current Interim Chief Executive Officer to our Board of Directors. Mr. Scorsis has over 25 years of experience leading companies in highly regulated industries to rapid growth. Mr. Cooper has over 27 years of management and finance experience.
“We are encouraged by the progress in our Phase 2 clinical trial of Ropidoxuridine for glioblastoma, with 63% enrollment having recently been achieved. Importantly, 72% of enrolled patients have completed all seven cycles with treatment reported as being well-tolerated,” commented Shuttle Pharma's interim Chief Executive Officer, Chris Cooper. “We are working closely with our primary third-party CRO, Theradex Systems, to continue execution of the clinical trial in combination with leading cancer centers across the U.S. Our goal continues to remain completion of enrollment later this year, with follow-up and data readouts anticipated in 2026.”
...
Read the full article here. -----
No. 4 SHPH Potential Catalyst - Multiple Technical Indicators Appear Oversold And Possibly Signal A Healthy Reversal Could Be Approaching.
At 4:00PM EST Friday, Barchart was reporting SHPH to have several oversold leaning technical indicators.
These technicals could be signaling a healthy reversal is approaching in the near term.
Here's the definition of a "reversal" from Investopedia:
"A reversal is a change in the price direction of an asset. A reversal can occur to the upside or downside. Following an uptrend, a reversal would be to the downside. Following a downtrend, a reversal would be to the upside. Reversals are based on overall price direction and are not typically based on one or two periods/bars on a chart."
Here's the technicals to pay close attention to (as of 4:00PM EST Friday):
- 9-Day Relative Strength Index: 28.93%
- 14-Day Relative Strength Index: 35.14%
When these numbers drop down to the 30% range and lower, they can be viewed as being in oversold territory. While in this territory, they can paint the picture of a profile that is undervalued.
- 14-Day Raw Stochastic %D: 5.16%
As the Raw Stochastic nears the 10% range and lower it may also be viewed as oversold and undervalued.
Keep an eye on these technicals closely. -----
No. 5 SHPH Potential Catalyst - The Company Has Achieved Multiple Partnerships For Cancer Diagnostics And Therapeutics Clinical Trial Development Support.
Shuttle Pharmaceuticals Holdings, Inc. maintains strategic agreements and contracts with academic institutions to access intellectual property, core facilities, and contracting relationships essential to its programs.
University of California, San Francisco (UCSF)
Shuttle entered a sponsored research agreement with UCSF to advance pre-clinical development of Shuttle Diagnostics, Inc.’s PSMA ligand as a potential theranostic molecule, led by principal investigator Robert Flavell, M.D., Ph.D.. The work aims to develop radiosynthetic methods for producing the [18F]FPA-ACUPA probe, investigate cellular binding in prostate cancer cell lines, and assess diagnostic potential across prostate cancer phenotypes; Shuttle holds an exclusive license to PSMA-B intellectual property and has filed a U.S. patent application.
Georgetown University
Georgetown University’s Lombardi Comprehensive Cancer Center supports discovery and development of cancer diagnostics and therapeutics, with Shuttle subcontracting SBIR-funded clinical work to establish cancer cell lines from African-American patients and develop predictive biomarkers for radiation late-effects sensitivity.
Brown University
Shuttle received an NIH SBIR contract for a Phase I clinical trial with Brown University at Lifespan/Rhode Island Hospital to determine the maximum tolerated dose in advanced gastrointestinal cancers, with NCI approving the protocol and providing drug and clinical data management support. The completed Phase I trial supports advancing Ropidoxuridine to Phase II trials in brain tumors, sarcomas, and other tumors.
University of Virginia
The University of Virginia, which developed “Atomic Radiation” intellectual property, collaborates with Shuttle scientists on sensitizers for use with proton radiation therapy.
George Washington Cancer Center
Collaborations between the Villagra lab at George Washington University and Shuttle’s lab led to an October 2020 AACR presentation on “Immune-mediated Tumor Growth Inhibition by Selective HDAC6 Inhibitor SP-2-225,” with Dr. Villagra serving as a Shuttle scientific advisor since 2017. A material transfer agreement supports testing HDAC inhibitor effects in immune model systems.
TCG GreenChem
TCG GreenChem Inc., part of the TCG Group with presence in the United States, India, and Japan, is a CRAMS company affiliated with TCG Lifesciences Pvt. Ltd. and joined Shuttle’s leadership team in 2020 to manufacture drug product for proposed clinical trials. TCG GreenChem has also been engaged to manufacture Ropidoxuridine and perform process R&D and optimization to support Shuttle’s clinical programs. -----
(Nasdaq: SHPH) Recap - These Potential Catalysts Could Provide A Breakout Spark
No. 1 - Could This Tiny Float Create A Scenario For Strong Volatility Potential?
No. 2 - A Binding Term Sheet Moves SHPH That Much Closer To A Game-Changing Acquisition.
No. 3 - A Recent Corporate Update Points To Transformative Company Milestones.
No. 4 - Multiple Technical Indicators Appear Oversold And Possibly Signal A Healthy Reversal Could Be Approaching.
No. 5 - The Company Has Achieved Multiple Partnerships For Cancer Diagnostics And Therapeutics Clinical Trial Development Support. -----
Now underway: coverage is initiated on Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH).
As soon as updates are available, I'll get them out the door to you. Talk shortly.
Sincerely, Kai Parker StockWireNews
(Always Remember The St-ock Prices Could Be Significantly Lower Now From The Dates I Provided.)
*StockWireNews.com (“StockWireNews” or “SWN” ) is owned by SWN Media LLC, a single member limited liability company. Data is provided from third-party sources and SWN is not responsible for its accuracy. Make sure to always do your own research and due diligence on any day and swing profile SWN brings to your attention. Any emojis used do not have a specific defined meaning, and may be used inconsistently. We do not provide personalized in-vest-ment advice, are not in-vest-ment advisors, and any profiles we mention are not suitable for all in-vest-ors.
Pursuant to an agreement between SWN Media LLC and TD Media LLC, SWN Media LLC has been hired for a period beginning on 11/02/2025 and ending on 11/03/2025 to publicly disseminate information about (SHPH:US) via digital communications. Under this agreement, SWN Media LLC has been paid twenty thousand USD ("Funds"). To date, including under the previously described agreement, SWN Media LLC has been paid thirty seven thousand five hundred USD ("Funds"). These Funds were part of the funds that TD Media LLC received from a third party who did receive the Funds directly or indirectly from the Issuer and does not own st-ock in the Issuer but the reader should assume that the clients of the third party own shares in the Issuer, which they will liquidate at or near the time you receive this communication and has the potential to hurt share prices.
Neither SWN Media LLC, TD Media LLC and their member own shares of (SHPH:US).
Please see important disclosure information here: https://stockwirenews.com/disclosure/shph-7e6wx/#details | 
