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Further Reading from MarketBeat.com Small-Cap Standouts: These 3 Stocks Rose Over 300% in 2025Reported by Leo Miller. Originally Published: 1/3/2026. 
Summary - While small caps as a whole generated lower returns than large caps in 2025, three interesting names bucked this narrative.
- A cancer screening company and two satellite operators saw their shares rise 300% or more.
- See where analysts are forecasting upside and understand vital considerations pertaining to smaller stocks.
In 2025, small-cap stocks underperformed. The Russell 2000 Index, which tracks the performance of 2,000 U.S. small-cap stocks, delivered a total return of about 13% in 2025. That lagged the S&P 500 Index's total return of roughly 18%, which tracks U.S. large-cap stocks. Despite the broader underperformance, three small-cap names stood out for exceptional returns in 2025. Below we detail three stocks that returned 300% or more. All three began 2025 as small-cap companies but, because of their gains, have since moved into mid-cap territory. GRAIL Catapults on Early Cancer Detection Enthusiasm Healthcare stock GRAIL (NASDAQ: GRAL) climbed roughly 380% in 2025. Its market capitalization moved from well below $1 billion to about $3.3 billion. GRAIL's flagship product is the Galleri Multi-Cancer Early Detection test. Early detection substantially improves cancer survival rates, which has driven investor interest in Galleri. Only about five cancer types have standardized screening programs, yet roughly 70% of cancer deaths are from other types. Galleri was developed to detect more than 50 different cancers. In a recent study, GRAIL said Galleri increased early cancer detection by more than seven times when added to traditional screening. Currently, Galleri generates most sales through out-of-pocket payments. GRAIL expects to apply for Premarket Approval (PMA) from the U.S. Food and Drug Administration in the first quarter of 2026. If approved, commercial insurers would be more likely to cover the test, opening a potentially large sales channel. The prospect of approval has been a major driver of investor enthusiasm. The MarketBeat consensus price target of $97.50 reflects analyst optimism and implies roughly 14% upside. PL Blasts Off, Combining AI with Geospatial Imagery Planet Labs PBC (NYSE: PL) had a blockbuster 2025, with shares rising just under 390%. Planet operates hundreds of satellites to capture medium- to high-resolution Earth imagery and combines that data with artificial intelligence to help customers make better decisions. The company generates revenue through subscriptions to its cloud platform and satellite services. Demand has been strong, particularly from government customers. Its Dec. 10 earnings report sent shares up 35% in a day, with defense and intelligence revenue rising more than 70%. Planet reported a backlog of about $735 million—roughly 2.6 times its last 12 months' revenue of $282 million—indicating substantial growth potential. The company also posted positive free cash flow for the second consecutive quarter. The MarketBeat consensus price target of $14.74 implies about 25% downside from current levels. However, the average of targets updated after the latest earnings report is $18.19, which suggests roughly 7.7% downside. Planet Labs remains worth watching; a meaningful pullback could present a more attractive entry point. Updated Targets Eye Strong Upside in VSAT After Huge 2025 Run Finally, Viasat (NASDAQ: VSAT) gained roughly 305% in 2025, giving it a market cap near $4.7 billion. Viasat is another satellite company but focuses on internet and data connectivity, serving aviation, maritime and government customers rather than primarily consumer telecom operators (similar to AST SpaceMobile (NASDAQ: ASTS)). Viasat provides in-flight connectivity to thousands of commercial and business aircraft. The U.S. government was the company's largest customer in fiscal 2025, accounting for 18% of revenue. (Viasat is currently in fiscal 2026.) Revenues rose just 2% last quarter, but contract awards increased 17% to nearly $1.5 billion, and backlog climbed to almost $3.9 billion. The MarketBeat consensus price target of $32.75 implies about 5% downside. However, targets updated after Viasat's Nov. 7 earnings report average $49, suggesting roughly 37% upside. GRAL, PL, VSAT: Deep Research Is Paramount GRAL, PL and VSAT delivered remarkable returns in 2025. That said, smaller companies—especially those that have run up dramatically—carry heightened risk and can be extremely volatile. Confidence in each company's long-term outlook is critical, so investors should conduct thorough due diligence before making investment decisions.
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