Plants and CancerPlants have also been a blessing to us and it shows positive results for cancer treatment.
GREETINGS FROM DRUGCHEM, Cancer has always been a global problem with many advances in treatment and prevention. Because they are printed by the cells of the human body, they cannot be controlled or stopped. Changes in the regulation of some important pathways that regulate cell proliferation and survival are responsible for the formation of all tumors. Transformations include loss of tumor suppressor genes, oncogenic alterations, and alterations in signal transduction pathways. Tumor suppressor genes are genes that prevent cell proliferation and tumor development. The nuclear phosphoprotein gene TP53 is the most important tumor suppressor gene among the 10.
Oncogenic transformation is a process of sequential addition of genetic and epigenetic changes that affect cell proliferation and survival. The signal transduction pathway involves the binding of extracellular signaling molecules and ligands to receptors located on the cell surface or within the cell that trigger events within the cell to elicit a response.
Herbal medicines are used as an important source of treatment in many developing countries. Many types of plants have been identified for their anti-cancer properties.
Compounds that have been recognized and extracted from terrestrial flora for his or her anticancer residences consist of polyphenols, brassinosteroids and taxols. Polyphenols are reducing agents and collectively with different nutritional reducing agents which include diet C, Vitamin E and Carotenoids called antioxidants, shield the body's tissues in opposition to oxidative pressure and related pathologies which include cancers, coronary coronary heart sickness and inflammation. Brassinosteroids are a sort of steroid hormones, basically vital for plant improvement and boom having the ability to set off apoptosis in most cancers cells. Taxol is the well known cancer drug in the US derived from the bark of Pacific yew tree.
Polyphenols may exert these anticancer effects through various mechanisms, including the elimination of carcinogenic agents, modulation of cancer cell signaling and cell cycle progression, promotion of apoptosis, and modulation of enzymatic activity. Anticancer drugs can be regulated by polyphenols that regulate acetylation, methylation, or phosphorylation through direct binding. Brassinosteroids are other natural compounds that have shown therapeutic value in the fight against cancer. A characteristic of cancer cells is that they do not naturally undergo apoptosis and grow indefinitely. However, brassinosteroids can induce the necessary responses to inhibit growth and induce apoptosis by interacting with the cell cycle. Along with their anticancer properties, Brassinosteroids induce differential responses in normal and cancer cells. A key feature in anticancer therapy is that the drug is non-cytotoxic to normal cells and specific to cancer cells. Here, the active ingredients of the origin of Brassinosteroids are interesting for their therapeutic properties. Medicines derived from plants are desirable for cancer treatment because they are natural and affordable. They can be safely introduced as part of the patient's diet. Since they are naturally derived compounds from plants, they are generally tolerated by normal human cells and are not toxic. However, there are exceptions such as cyanogenic glycosides, lectins, saponins, lignans, lectins, and some taxanes. If plant-derived drugs show selectivity in research, are nontoxic to normal cell lines, and cytotoxic to cancer cell lines, these drugs can be entered into clinical trials for further therapeutic development. Medicines derived from plants can fall into four groups of drugs with the following activities; Methyltransferase inhibitors, drugs to prevent DNA damage or antioxidants, histone deacetylase (HDAC) inhibitors, and mitotic disruptors. DNA methyltransferase (DNMT) inhibitors are drugs used to study the role of DNA methylation in tissues and model systems, and these compounds represent a potential therapeutic option for diseases associated with altered DNA methylation. Marked changes in DNA methylation are called "epimutations" and appear to play an important role in carcinogenesis. The consequences of an epimutation are similar to classical genetic mutations because the affected genes are silenced and no functional gene product is produced. Antioxidants are man-made or natural substances that can prevent or delay certain types of cell damage. Antioxidants work by scavenging free radicals and neutralizing their harmful effects. This helps keep the body's cells healthy and less prone to cancer. paraphraser. Cancer patients and people at risk of cancer should avoid taking antioxidants. Histone deacetylase (HDAC) inhibitors are a relatively new class of anticancer drugs that play an important role in epigenetic or non-epigenetic regulation by inducing death, apoptosis, and cell cycle arrest in cancer cells. Histone deacetylase (HDAC) is an enzyme that removes the acetyl group from DNA histone proteins, making the DNA less accessible to transcription factors. A mitotic inhibitor is a drug that prevents mitosis or cell division. These drugs destroy microtubules, structures that separate chromosomes during cell division. PLANT-DERIVED DRUGS IN RESEARCH AND CLINICAL TRIALS: Sulforaphane: Sulforaphane is a powerful phytochemical and studies show that it can protect your body from cancer. It is isolated from Isotiocynanate in cruciferous vegetables Brassica.
Some studies have shown that sulforaphane blocks mutations in DNA that cause cancer. It can slow the growth of tumors. Sulforaphane reduces the ability of cancer cells to grow. This means it can slow the growth of a tumor or its ability to spread to other parts of your body. Sulforaphane content is high in broccoli, cauliflower, Brussel sprouts, cabbage etc. Vincristine: Vincristine is a vinca alkaloid isolated from the leaves of the Madagascar catharanthus roseus, formerly known as Vinca rosea. Although the plant extracts were not very effective in lowering blood sugar in the mice, they significantly reduced the white blood cell count. Because some cancers, such as leukemia, involve white blood cells, researchers quickly realized that Madagascar periwinkle extracts may contain a chemical (or chemicals) with potential cancer-fighting properties.
and many more…. Plant-derived anticancer drugs are potent inhibitors of cancer cell lines and are therefore in high demand. Hope you like this one. Stay tuned for more.
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