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This Week's Featured Article Why 2 Small Biotechs May Hold the Key to New Cancer TreatmentsSubmitted by Nathan Reiff. Date Posted: 3/12/2026. 
Summary - Iovance and ImmunityBio each have a leading oncology product that has helped to massively boost sales and share prices in recent quarters.
- Despite major gains in recent trading, IOVA and IBRX shares still have at least 70% in upside potential going forward, according to analysts.
- Profitability remains a concern for both companies, even as sales of their top cancer drugs have surged.
Cancer remains one of the greatest medical challenges for biotechnology firms, even as the oncology medicine market is expected to grow to $366 billion over the next eight years. Companies often take a niche approach, developing medicines that target specific cancers with tailored mechanisms. Fortunately, a number of promising treatments have shown strong potential—and with that comes the possibility of significant sales. Two smaller biotech companies are enjoying notable share-price momentum thanks to their leading oncology medicines. Beyond therapeutic promise, these drugs could help the firms move toward greater stability and, potentially, long-term profitability. That said, both remain high-risk investments: each faces clinical, regulatory, or commercial hurdles that could limit upside even as the rewards for success are substantial. Iovance's Powerful Cancer Drug Is Growing, But Production Challenges Are a Hurdle Med-X is gearing up for a possible Nasdaq listing (ticker: MXRX). But the real opportunity is now – before they hit the big stage.
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With $6.4M in sales in just four years, they're getting ready for the next step. Become a Med-X Shareholder Before Their Nasdaq Plans Unfold Iovance Biotherapeutics Inc. (NASDAQ: IOVA) bucked market trends in early March, jumping nearly 37% in a week when the S&P 500 slipped about 1%. That rally added to IOVA's strong year-to-date performance, with shares more than doubling so far. Still, with a consensus price target of $8.88, Wall Street sees further upside—implying roughly 71% more gains from current levels. The main catalyst behind Iovance's move is its lead therapy, Amtagvi, a T‑cell immunotherapy for certain types of melanoma. Amtagvi has been approved in the United States since 2024 and is building commercial momentum, with additional approvals likely in the E.U., U.K., and elsewhere. When administered with Proleukin, the company's IL‑2 immunotherapy, management believes Amtagvi could exceed $1 billion in peak annual U.S. sales. Its potential may extend beyond melanoma: Amtagvi received FDA Fast Track designation for non‑small cell lung cancer and is being evaluated for other tumor types. Some of Iovance's outperformance this year also reflects its Q4 2025 earnings report, issued in late February, in which the company posted narrower‑than‑expected losses per share and reported $5 million in revenue. For the full year, revenue rose roughly 30% year over year. Iovance is still considered a small (about $2 billion) biotech, and despite the rally, analysts remain cautious—about half of its roughly dozen ratings are Hold or Sell. Risks are significant: in addition to typical small‑biotech concerns, Amtagvi is a personalized therapy that is costly and complex to manufacture. That manufacturing profile could constrain margins and profitability even as demand increases. Massive Sales Growth for ImmunityBio's Bladder Cancer Drug Although ImmunityBio Inc. (NASDAQ: IBRX) fell about 20% in March, its year‑to‑date performance far outpaces Iovance's. IBRX shares are up nearly 300% in 2026, and analysts remain optimistic: the consensus price target is $13.60, roughly 70% above the stock's current level. ImmunityBio's primary growth driver is Anktiva, a treatment for certain forms of bladder cancer. In February, shares jumped after the E.U. regulator granted conditional marketing authorization—one of several recent approvals globally. Anktiva is already material to the company's top line: the drug generated $113 million in sales last year, a roughly 700% year‑over‑year increase. Like Amtagvi, Anktiva may have potential in other cancer indications, and ImmunityBio is actively exploring additional regulatory designations. Despite the strong recent performance, IBRX remains speculative and risky. The company reported a full‑year net loss of $351 million for 2025 as R&D and other expenses remain elevated. Analysts, however, are relatively bullish on ImmunityBio compared with Iovance: six out of seven covering the stock rate it a Buy or equivalent.
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